Heterogeneity of Microarray-based Lung Cancer Signature in Patients with Lung Cancer

Dr. Shofer’s research builds on work of earlier investigators who developed a lung cancer risk signature based on genetic changes in lung cells in smokers. Dr. Shofer hypothesizes that the lung cancer risk signature model is an indicator of how lung cells change during the process of cancer development. Should his hypothesis be correct, the lung cancer risk signature could be established as a sensitive biomarker capable of diagnosing patients with lung cancer by checking cells taken from the throat using a swab.