MI

Autoantibody biomarkers for the detection of lung cancer

Funded equally by LUNGevity Foundation and the American Lung Association
Michael Tainsky, PhD
Wayne State University, Karmanos Cancer Institute
Detroit

Dr. Tainsky has developed a technology that takes advantage of the responses of the human immune system to identify cancer-associated proteins that bind to antibodies present in the blood of cancer patients but not in the blood of healthy subjects or those with benign diseases. Dr. Tainsky is working to develop a non-invasive screening test for the early detection of lung cancer by using cancer-associated antigens as biomarkers.

Regulation of Myc and micoRNA in small cell lung cancer

LUNGevity Foundation/Uniting Against Lung Cancer Research Grant
Mats Ljungman, PhD
University of Michigan
Ann Arbor

Small cell lung cancer cells produce high amounts of myc protein.  The myc protein makes cancer cells resistant to chemotherapy. Dr. Ljungman is investigating why small cell lung cancer makes high amounts of the myc protein and how this can be reversed.