Targeted Combination Therapy for Lung Cancer Carcinogenesis

Targeted Therapeutics Research Award
Funded by LUNGevity Foundation in collaboration with The CHEST Foundation, the philanthropic arm of the American College of Chest Physicians
William Jeffrey Petty, MD
Dartmouth-Hitchcock Medical Center
Lebanon
NH

Bexarotene is a synthetic form of retinoid acid (Vitamin A) that has the potential for use in lung cancer chemoprevention. Dr. Petty is conducting a clinical trial with a treatment combination of bexarotene and erlotinib (Tarceva) in EGFR-positive patients who have metastatic non-small cell lung cancer (NSCLC). He is also evaluating biomarkers that will predict response to the combination regimen.