Notch signaling regulates lung cancer

Targeted Therapeutics Research Award
Funded by LUNGevity Foundation and Arkansas Respiratory Health Association, Breathe California of Los Angeles County, Breathe California of the Bay Area, Breathe New Hampshire, and Respiratory Health Association of Metropolitan Chicago
Navdeep Chandel, PhD
Feinberg School of Medicine, Northwestern University
Chicago
IL

Dr. Chandel is working to identify novel pathways underlying KRAS-driven lung cancer. He is testing two pathways, to determine how mitochondria (powerhouses of the cell) and Notch signaling (a pathway often activated in lung cancer that relays information from outside the cell to inside) behave differently in cancer and non-cancer cells.